Taking 60mg of prednisone at once is a high dose and carries significant risks. This isn’t a typical starting dose and should only be done under strict medical supervision.
High-dose prednisone can cause serious side effects, including:
| Increased blood sugar | Prednisone can raise blood glucose levels, potentially worsening diabetes or causing hyperglycemia. Regular blood sugar monitoring is crucial. |
| Fluid retention | You might experience swelling in your legs, ankles, and feet due to sodium and water retention. |
| High blood pressure | Prednisone can elevate blood pressure, requiring careful monitoring and potential adjustments to medication. |
| Increased risk of infection | Prednisone suppresses the immune system, making you more susceptible to infections. |
| Mood changes | Irritability, anxiety, and insomnia are common side effects. |
| Gastrointestinal issues | Stomach upset, nausea, heartburn, and ulcers are possible. |
| Muscle weakness | Prednisone can weaken muscles, leading to potential falls and injuries. |
| Bone loss (osteoporosis) | Long-term high-dose prednisone can weaken bones, increasing fracture risk. |
| Cushing’s syndrome (long-term high dose) | Prolonged high-dose use can lead to Cushing’s syndrome, characterized by weight gain, facial changes, and other metabolic disturbances. |
If your doctor prescribes a 60mg dose, follow their instructions carefully. Discuss any concerns or side effects immediately. Regular monitoring of your blood pressure, blood sugar, and other relevant parameters is essential. Remember, this is not a self-treating situation. Always consult your physician before making any changes to your medication regimen.


