Adcirca (tadalafil) targets pulmonary arterial hypertension (PAH) by relaxing blood vessels in the lungs. However, it’s not a one-size-fits-all solution. Your doctor will consider several factors when choosing the right treatment for you.
Other PAH treatments include endothelin receptor antagonists (ERAs) like bosentan and ambrisentan, which block the effects of endothelin, a substance that constricts blood vessels. Phosphodiesterase-5 inhibitors (PDE5-is), such as sildenafil and revatio, work similarly to Adcirca by improving blood flow. Prostacyclin analogs, such as treprostinil and epoprostenol, are powerful vasodilators that directly improve blood flow in the lungs. Finally, guanylate cyclase stimulators, such as riociguat, increase levels of cGMP, causing vasodilation.
The choice depends on your specific condition, other health issues, and your response to medication. Some patients benefit from combination therapy, using multiple drugs simultaneously. Side effects vary widely across these treatments. For instance, Adcirca may cause headaches, back pain, and flushing; ERAs can affect liver function; and prostacyclin analogs can cause jaw pain.
| PDE5 Inhibitors | Adcirca (tadalafil), Revatio (sildenafil) | Relax blood vessels | Headache, flushing, back pain |
| Endothelin Receptor Antagonists (ERAs) | Bosentan, Ambrisentan | Block endothelin’s effects | Liver enzyme elevation, headache, edema |
| Prostacyclin Analogs | Treprostinil, Epoprostenol | Directly dilate blood vessels | Jaw pain, headache, flushing |
| Guanylate Cyclase Stimulators | Riociguat | Increase cGMP levels | Headache, dizziness, diarrhea |
Regular monitoring of your condition and medication response is crucial. Discuss any concerns or side effects with your doctor promptly. They will help you find the most suitable and safe treatment plan for your individual needs.
