Avoid Zofran IV push in patients with known hypersensitivity to ondansetron or its components. This includes a history of allergic reactions such as rash, itching, or swelling.
Cardiac Considerations
Monitor patients closely for prolonged QT interval, especially those with pre-existing cardiac conditions or taking medications that prolong the QT interval (e. g., certain antiarrhythmics, antibiotics). A baseline electrocardiogram (ECG) might be beneficial before administering Zofran, particularly in high-risk individuals. Discontinue Zofran if significant QT prolongation occurs.
Hepatic Impairment
Reduce the Zofran dosage for patients with hepatic impairment due to reduced drug clearance. Closely monitor these patients for adverse effects.
Concurrent Medications
Be aware of potential drug interactions. Ondansetron may interact with certain medications, altering their metabolism or efficacy. Consult relevant resources for specific interaction details.
Neurological Effects
Though rare, Zofran can cause neurological side effects such as headache, dizziness, and rarely, seizures. Patients with a history of seizures should be monitored closely.
Pregnancy and Breastfeeding
Use Zofran during pregnancy only if the benefit clearly outweighs the potential risks to the fetus. Data on the excretion of ondansetron in breast milk is limited; consider this factor when making prescribing decisions for breastfeeding mothers.
Post-operative Setting
In the postoperative setting, carefully monitor patients for delayed gastric emptying and potential complications from this side effect.
Dosage and Administration
Strictly adhere to recommended dosage and administration guidelines. Rapid IV administration may increase the risk of adverse effects. Always follow the manufacturer’s instructions for proper dilution and administration rate.
Monitoring
Regularly assess patients for any signs of adverse reactions, including changes in heart rhythm, neurological symptoms, or hepatic dysfunction. Promptly report and manage any serious adverse events.
