Always inform your doctor about all medications you take, including over-the-counter drugs, herbal supplements, and recreational drugs, before starting Sildenafil. This is crucial for preventing harmful interactions. Nitrate-containing medications, such as nitroglycerin, are strictly contraindicated due to the risk of dangerously low blood pressure.
Specific Interactions to Note
Sildenafil’s interaction with alpha-blockers, used to treat high blood pressure or enlarged prostate, can cause significant drops in blood pressure. Similarly, combining Sildenafil with certain antifungals (like ketoconazole or itraconazole) or HIV protease inhibitors (like ritonavir) can increase Sildenafil’s concentration in the blood, potentially leading to side effects. Concomitant use with strong CYP3A4 inhibitors should be approached with caution.
Patients with severe heart or liver problems, uncontrolled high blood pressure, or a history of stroke or heart attack should avoid Sildenafil. Those with rare inherited eye diseases like retinitis pigmentosa should also exercise extreme caution. Alcohol consumption should be moderate as it can enhance Sildenafil’s side effects. Finally, inform your doctor about any pre-existing conditions before taking Sildenafil to ensure safe usage.
