Hydroxyzine can interact with several medications, potentially altering their effects or causing adverse reactions. Always inform your doctor or pharmacist of all medications, including over-the-counter drugs, supplements, and herbal remedies, you are taking before starting hydroxyzine.
Central Nervous System Depressants
Combining hydroxyzine with other central nervous system depressants, such as opioids (codeine, morphine), benzodiazepines (diazepam, alprazolam), or alcohol, significantly increases the risk of drowsiness, sedation, and respiratory depression. This combination should be avoided unless specifically prescribed by a physician, and even then, close monitoring is necessary.
Anticholinergic Medications
Hydroxyzine’s anticholinergic properties can be amplified when taken with other anticholinergic drugs like antihistamines (diphenhydramine, chlorpheniramine), certain antidepressants (tricyclic antidepressants), or antiparkinsonian medications. This combination can lead to increased dry mouth, blurred vision, constipation, and urinary retention. Your doctor might need to adjust dosages or choose alternative medications.
Monoamine Oxidase Inhibitors (MAOIs)
Concurrent use of hydroxyzine and MAOIs can cause a potentially dangerous increase in blood pressure. A significant time gap (generally two weeks) should separate the use of MAOIs and hydroxyzine. Consult your physician for precise guidance on this interaction.
Other Interactions
Hydroxyzine may interact with certain medications affecting the liver enzymes (CYP450). This can affect how the body processes both hydroxyzine and other drugs, leading to altered drug levels and potential side effects. Examples include some antidepressants and anti-anxiety medications. Always consult your physician or pharmacist for personalized advice.
