Interactions with Other Medications

Always inform your doctor about all medications you’re taking, including over-the-counter drugs, supplements, and herbal remedies. Prednisone can interact with many medications, altering their effectiveness or increasing the risk of side effects.

Nonsteroidal anti-inflammatory drugs (NSAIDs): Combining prednisone with NSAIDs like ibuprofen or naproxen raises your risk of stomach ulcers and bleeding. Monitor for stomach pain or dark, tarry stools. Your doctor might adjust your dosage or suggest alternative pain relievers.

Blood thinners (anticoagulants): Prednisone can interact with warfarin and other anticoagulants, potentially increasing bleeding risk. Close monitoring of your blood clotting time is necessary. Your doctor will likely adjust dosages to maintain a safe balance.

Digoxin: Prednisone can increase the effects of digoxin, a medication used to treat heart conditions. This could lead to irregular heartbeat or other cardiac problems. Regular monitoring of your heart rate and rhythm is crucial.

Diabetes medications: Prednisone can elevate blood sugar levels, potentially requiring adjustments to your diabetes medication. Careful monitoring of your blood glucose is vital. Consult your doctor or diabetes specialist for guidance.

Note: This is not an exhaustive list of potential drug interactions. Always consult your physician or pharmacist before starting or changing any medication while taking prednisone. They can provide personalized advice based on your medical history and current medications.