Always inform your doctor and pharmacist about all medications, supplements, and herbal remedies you are taking before starting naproxen. This includes over-the-counter drugs like aspirin and ibuprofen.
Increased Risk of Bleeding
- Naproxen can increase the risk of bleeding, especially when combined with blood thinners like warfarin (Coumadin) or aspirin. Monitor for unusual bleeding or bruising. Nonsteroidal anti-inflammatory drugs (NSAIDs), including naproxen, may interact negatively with antiplatelet drugs like clopidogrel (Plavix). Consult your doctor before combining these medications.
Gastrointestinal Issues
Taking naproxen with other medications that can irritate the stomach, such as corticosteroids or other NSAIDs, may increase the risk of stomach ulcers or bleeding. Your doctor may recommend taking a protective medication, such as a proton pump inhibitor, to mitigate this risk.
Kidney Problems
- Naproxen can reduce kidney function, especially when combined with diuretics (“water pills”) or ACE inhibitors, medications often prescribed for high blood pressure or heart failure. Close monitoring of kidney function may be necessary. Lithium levels in the blood can be affected by naproxen. Your doctor will need to monitor your lithium levels if you are taking both medications.
Other Interactions
Naproxen may affect how certain medications for diabetes work. Your doctor might need to adjust your diabetes medication dosage. Some antibiotics, such as methotrexate, can have increased side effects when taken with naproxen. This interaction requires careful monitoring. The efficacy of some blood pressure medications can be affected when taken alongside naproxen.
Alcohol
Combining naproxen with alcohol can increase the risk of stomach upset and bleeding. Limit alcohol consumption while taking naproxen.
Consult Your Doctor
This information does not cover all possible interactions. It is crucial to discuss all your medications and supplements with your healthcare provider before taking naproxen, to prevent potentially harmful interactions.
