Stop Clozaril administration immediately if you observe agranulocytosis (severe drop in white blood cells), indicated by a neutrophil count below 1500/µL or an absolute lymphocyte count below 500/µL. Obtain complete blood counts (CBC) without delay.
For severe myocarditis or cardiomyopathy, immediately discontinue Clozaril and initiate supportive care, including close cardiac monitoring. ECG and echocardiogram are vital.
Neuroleptic malignant syndrome (NMS) requires immediate hospitalization. Discontinue Clozaril. Focus on supportive care: fluid management, temperature control, and symptom management. Consider dantrolene or bromocriptine for symptom relief.
Severe seizures necessitate immediate cessation of Clozaril and potentially anticonvulsant medication. Implement seizure precautions and carefully monitor the patient’s neurological status.
For any severe allergic reactions (e. g., anaphylaxis), administer epinephrine immediately according to established guidelines. Provide supportive care and manage respiratory compromise.
Document all adverse reactions meticulously, including timing, severity, and interventions taken. Notify the prescribing physician immediately regarding any severe adverse event. Closely monitor the patient’s condition and adjust treatment plans accordingly.
