Prednisone, a corticosteroid, can indirectly raise estrogen levels in men, leading to gynecomastia (breast enlargement). This occurs because prednisone influences the liver’s function. The liver plays a critical role in metabolizing hormones, including sex hormones like estrogen and testosterone.
How Prednisone Affects Hormone Metabolism
Prednisone can interfere with this metabolic process. It can inhibit the liver’s ability to properly break down estrogen, resulting in higher circulating estrogen levels. Simultaneously, prednisone can also suppress testosterone production. This imbalance–increased estrogen and decreased testosterone–creates an environment that favors the development of gynecomastia. The severity depends on individual factors like dosage, duration of treatment, and pre-existing conditions.
Understanding the Individual Risk
Factors such as age, genetics, and overall health contribute to an individual’s susceptibility to prednisone-induced gynecomastia. Men with a predisposition to hormonal imbalances may experience more pronounced effects. It’s crucial to discuss any concerns about breast changes with your doctor. They can assess your specific risk and advise on appropriate management strategies.
