The rash associated with amoxicillin use during mononucleosis usually resolves on its own once the amoxicillin is stopped. Discontinuing the amoxicillin is the primary treatment for this reaction.
Managing Symptoms
While the rash subsides, you can manage discomfort with over-the-counter medications. Antihistamines like diphenhydramine (Benadryl) or cetirizine (Zyrtec) can alleviate itching. Cool compresses or oatmeal baths can also soothe irritated skin. For more severe itching or extensive rash, consult your doctor; they might prescribe a topical steroid cream or a stronger antihistamine.
When to Seek Medical Attention
Although most rashes are mild and resolve quickly, seek immediate medical attention if you experience difficulty breathing, swelling of the face or throat, or widespread hives. These symptoms could indicate a severe allergic reaction requiring immediate medical intervention.
