Doxycycline prevents malaria by inhibiting bacterial protein synthesis. Specifically, it binds to the 30S ribosomal subunit of susceptible bacteria, blocking the attachment of aminoacyl-tRNA to the mRNA-ribosome complex. This halts further protein production, ultimately leading to bacterial death.
Its efficacy against malaria is proven, but varies depending on the species of Plasmodium and the prevalence of resistance.
- Against Plasmodium falciparum, doxycycline provides prophylaxis, but resistance is emerging, so efficacy isn’t guaranteed in all regions. It’s generally less effective against Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae compared to other antimalarials.
Proper dosage and duration are critical. Typical regimens for malaria prophylaxis involve daily doses. Deviating from prescribed schedules reduces the drug’s effectiveness. Consult your doctor for detailed guidelines, as duration varies depending on risk factors and travel destination.
Always follow your doctor’s prescribed dosage and schedule. Complete the full course of treatment, even if symptoms improve. Be aware that some medications may interact with doxycycline. Discuss potential interactions with your physician. Report any side effects promptly to your healthcare provider.
While generally well-tolerated, doxycycline can cause side effects like nausea, vomiting, diarrhea, and photosensitivity. These are usually mild and temporary. Severe reactions are rare but require immediate medical attention.
