Always inform your doctor about all medications you are taking, including over-the-counter drugs, herbal remedies, and recreational drugs. Sildenafil can interact negatively with several substances.
Nitrates
Combining Sildenafil with nitrates (found in medications for chest pain) can cause a dangerous drop in blood pressure. This combination should be strictly avoided.
Alpha-blockers
Alpha-blockers, often prescribed for high blood pressure or enlarged prostate, can enhance Sildenafil’s blood pressure-lowering effects. Your doctor may adjust your dosage or recommend alternative treatments.
CYP3A4 Inhibitors
Medications that inhibit the CYP3A4 enzyme (like ketoconazole, erythromycin, ritonavir) can increase Sildenafil levels in your blood, potentially increasing side effects. Your doctor might need to lower your Sildenafil dose.
CYP3A4 Inducers
Conversely, medications that induce CYP3A4 (like rifampicin, St. John’s Wort) can decrease Sildenafil’s effectiveness. Your doctor might need to adjust your dosage accordingly.
Alcohol
Excessive alcohol consumption can intensify Sildenafil’s side effects, including dizziness and headaches. Moderate alcohol intake is generally advised.
Other Potential Interactions
| Blood thinners (anticoagulants) | Increased risk of bleeding |
| High blood pressure medications (other than alpha-blockers) | Potential blood pressure changes; dosage adjustments may be necessary. |
| Certain antidepressants | Potential for increased side effects |
This information is not exhaustive. Always consult your doctor or pharmacist before starting or stopping any medication, especially if you’re taking Sildenafil.
